LaTheta LCT-100A™: In-vivo CT scanner for small animals

| LaTheta™ Description | LaTheta™ Applications | LaTheta™-related Articles |

	LaTheta™ CT Scanner
	Click on the picture for a larger image.

LaTheta™ Description

Designed for small animals and intended especially for the in-vivo and ex-vivo animal research, the LaTheta™ CT scanner possesses several distinctive features. For example, its extremely sensitive detector allows working with low energy x-ray source, making possible longitudinal studies. Very fast scanning and reconstruction times of its detector allow seeing the result during the acquisition, aborting, and changing the parameters, after the first slice is displayed. In addition, high contrast and low noise level provide a good resolution of tissues with similar density, such as visceral organs.

Furthermore, LaTheta™ accommodates a wide range of animals, thus allowing rats up to 1.5 kg to be scanned. Its quantification of the scanned images implemented in the software includes visceral, subcutaneous, and total fat volume, BMD, mechanical strength and morphology with automatic cortical/trabecular bone recognition, etc. The LaTheta software is very easy to operate and does not require special training. Finally, LaTheta™ is compact and portable. Combined with the very low outside radiation of LaTheta™, these features allow using this instrument in any room.

Specifications for LaTheta LCT-100A™.

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	Images of a guinea pig taken by LaTheta™
	Click on the picture for a larger image.

Application Examples:

• Visceral versus subcutaneous fat measurement
• Fatty liver characterization
• Brown fat and white fat differentiation
• Bone measurements

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LaTheta™-related Articles

To learn more about the research conducted with the LaTheta™ CT scanner, you could look at the following scientific papers:

1. Keitaro Yamanouchi et al. (2004) Analyses of hind leg skeletons in human growth hormone transgenic rats. Experimental Gerontology, 39:1179-1188.
2. Hiroshi Iwakura et al. (2005) Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. J. Biol. Chem, Vol. 280, Issue 15, 15247-15256.
3. Takashi Shimada et al. (2005) Vitamin D receptor-independent FGF23 actions in regulating Phosphate and vitamin D metabolism. Am. J. Physiol. Renal Physiol., 289:F1088-F1095.
4. WuQiang Fan et al. (2005) Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion. Diabetes, 54:1000-1008.
5. Yuichi Oike et al. (March 2005) Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nature Medicine, 11:400-408.
6. Yoshinori Arai, Ayuta Yamada, Tadashi Ninomiya, Takafumi Kato, Yuji Masuda (June 2005) Micro-computed tomography newly developed for in vivo small animal imaging. Oral Radiology, Vol. 21, No. 1:14-18.
7. Hikaru Morisue, Morio Matsumoto, Kazuhiro Chiba, Hideo Matsumoto, Yoshiaki Toyama, Mamoru Aizawa, Nobuyuki Kanzawa, Takahiro J. Fujimi, Hiroshi Uchida, Isao Okada (May 15, 2006) A novel hydroxyapatite fiber mesh as a carrier for recombinant human bone morphogenetic protein-2 enhances bone union in rat posterolateral fusion model. Spine 31(11):1194-1200.
8. Adam Glowalla (June 2-4, 2006) Computed tomography as a non-destructive method for reduction of animal use.13th Congress on Alternatives to Animal Testing, University of Linz, Linz, Austria.
9. Toru Nishiwaki et al. (April 2006) Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. Journal of Bone and Mineral Research, 21:596-604.
10. Satoshi Kanazawa, Shusuke Ota, Chiyoko Sekine, Toyohiro Tada, Takanobu Otsuka, Takashi Okamoto, Grete Sonderstrup, B. Matija Peterlin (Sept. 2006) Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis. PNAS Vol. 103, No. 39:14465-14470.
11. Takehiro Torisu, Naoichi Sato, Daigo Yoshiga, Takashi Kobayashi, Tomoko Yoshioka, Hiroyuki Mori, Mitsuo Iida, Akihiko Yoshimura (2007) The dual function of hepatic SOCS3 in insulin resistance in vivo. Genes to Cells 12(2):143–154.
12. Shankar, K., Harrell, A., Liu, X., Ronis, MJJ., Badger, TM. (April 28-May 2, 2007) Increased adipose de novo lipogenesis underlies high carbohydrate driven obesity: role of ChREBP. Experimental Biology 2007. Today's Research: Tomorrow's Health, Washington, DC.

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