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Systems for Mice
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Combo Systems for Rats and Mice
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3-in-1 Systems
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4-in-1 Systems
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Custom-built Systems
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Systems for Humans
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CT Scanners
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EchoMRI™: features and benefits
The key benefit of the EchoMRI™ systems
to those involved in research is the precision and accuracy they offer
when compared to those of DEXA. When Nuclear Magnetic Resonance (NMR)
is applied toward the analysis of body composition during clinical
trials, it has an effect on the accuracy, precision,
sensitivity, and specificity of results. It is far superior in its ability to offer precise and accurate results for researchers and clinicians.
Precision: Precision
of fat measurement by EchoMRI™ in mice i about 25 times higher
than DEXA. This higher precision allows researchers to reduce
considerably the number of treated subjects and controls during drug
development and testing.
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Sensitivity: The
high sensitivity of EchoMRI™ allows less compound to be
administered for each animal while achieving a measurable response.
Statistically significant detection of differences of small magnitude
in body composition allows the dose of a tested compound to be reduced,
and therefore, substantially reduces its toxicity effect.
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Specificity: The
high specificity of EchoMRI™ technology isolates and focuses on
the accurate measurement of fat content instead of less relevant
non-disease parameters, such as body weight or nonfat masses. The
specificity of EchoMRI™ measurement is based on molecular
physical principals, unlike any of its competitors, and unlike DEXA,
all measured parameters are easy to interpret.
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Accuracy: The
EchoMRI™ whole body composition analyzer is designed to provide
high accuracy for screening, while DEXA and other technologies have low
accuracy capabilities. On the other hand, with DEXA, subjective
threshold values can cause subjective results. Live and dead animals
have large differences in values. The equipment cannot be calibrated
against 100% fat or lean, introducing errors. The fat and lean in the
head is omitted from results, and the spine core fat is under-detected.
On a DEXA projection, 40% of the image is covered by bone, so there are
large errors in fat and lean measurements.
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No Need for Anesthesia or Sedation: EchoMRI™
measurement of moving bodies is non-invasive, with no anesthesia or
sedation required. Animals are able to move freely. Thus, having no
need for anesthesia or sedation saves time and reduces the 2-day impact
on animal behavior from gas or injected anesthesia required for DEXA.
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Fast Measurements: The
measuring technique is optimized for the maximum measuring precision of
whole body fat, muscle, and body fluids, while keeping the total
measurement time to about one minute for rats and mice. With DEXA, the
time of measurement is 5 minutes, and preparation and recovery for each
animal can take up to 2 days.
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Safety: The
static magnetic field is completely shielded and this prevents
containment issues in the outside and internal environment, including
the internal shielding of radio frequency (RF) magnetic and electrical
fields. DEXA x- ray equipment requires adherence to regulations.
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Mobility: The
equipment is transportable on wheels and can be moved by one person
from place to place. It is easy to assemble and service.
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Self-Testing: Daily tuning occurs through automated system tests and testing procedures with self- correcting adjustments.
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Validity and Reliability: EchoMRI™
technology and systems are used by leading pharmaceutical companies and
research institutions. The products are well-tested and highly
reliable. The measurements taken cannot be altered, and results are
100% operator independent. Unlike DEXA, no training is required.
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